Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Polytriazoles as copper(I)-stabilizing ligands in catalysis.

Timothy R Chan1, Robert Hilgraf, K Barry Sharpless

  • 1Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, California 92037, USA.

Organic Letters
|August 28, 2004
PubMed
Summary

Copper(I)-catalyzed reactions were improved using polytriazolylamines. The tris-benzyltriazoleamine (TBTA) ligand stabilized copper(I) catalysts, enhancing their activity and preventing degradation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Identification of chemical features for improved outer membrane permeation in mycobacteria using machine learning.

Nature microbiology·2026
Same author

Alkyl sulfonyl fluorides as ambiphiles in the stereoselective palladium(II)-catalysed cyclopropanation of unactivated alkenes.

Nature synthesis·2026
Same author

Mapping Nonlinear Solvation at the Air-Organic-Solution Interface Using an Azide Probe.

The journal of physical chemistry letters·2026
Same author

Where's the Salt? Sensing the Ionic Environment of the Air-Organic-Water Interface Using an Azide Probe.

Angewandte Chemie (International ed. in English)·2025
Same author

Hydrolysis Kinetics at the Air-Water Interface.

Journal of the American Chemical Society·2025
Same author

SuFEx-based antitubercular compound irreversibly inhibits Pks13.

Nature·2025

Area of Science:

  • Organic Chemistry
  • Catalysis
  • Materials Science

Background:

  • Copper(I) catalysis is crucial in organic synthesis.
  • Copper(I) catalysts are prone to oxidation and disproportionation, limiting their utility.
  • Developing effective ligands is key to stabilizing copper(I) species.

Purpose of the Study:

  • To synthesize novel polytriazolylamines.
  • To evaluate their efficacy as ligands for copper(I) catalysis.
  • To investigate the stabilizing properties of a C3-symmetric derivative, TBTA.

Main Methods:

  • Synthesis of polytriazolylamines via copper(I)-catalyzed azide-alkyne cycloaddition (click chemistry).
  • Characterization of synthesized compounds.
  • Testing the performance of TBTA as a ligand in copper(I)-catalyzed reactions.

Related Experiment Videos

Main Results:

  • Successful synthesis of polytriazolylamines.
  • TBTA demonstrated significant stabilization of copper(I) against oxidation and disproportionation.
  • TBTA enhanced the catalytic activity of copper(I) in the studied reactions.

Conclusions:

  • Polytriazolylamines are effective ligands for copper(I) catalysis.
  • TBTA is a powerful stabilizing ligand for copper(I), improving catalyst performance and longevity.
  • The C3-symmetric nature of TBTA contributes to its stabilizing properties.