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Studies on a novel safety-catch linker cleaved by Pummerer rearrangement
Chih-Ho Tai1, Hsiao-Ching Wu, Wen-Ren Li
1Department of Chemistry, National Central University, Chung-Li, Taiwan, 32054.
Organic Letters
|August 28, 2004
Abstract:
We describe the use of a sulfide linkage as a safety-catch linker. This linker is significantly stable to acidic as well as basic conditions and allows transformations to be carried out on solid supports. Moreover, its cleavage is facile by applying Pummerer rearrangement after transforming it to sulfoxide.