Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Search for disease-specific cardiovascular reactivity patterns: developing the methodology.

Jochanan E Naschitz1, Michael Rozenbaum, Madeline Fields

  • 1Department of Internal Medicine A, Bnai Zion Medical Center and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel. Naschitz@tx.technion.ac.il

Clinical Science (London, England : 1979)
|August 28, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prediction of OncotypeDX recurrence score using hematoxylin and eosin-stained whole slide images.

NPJ breast cancer·2026
Same author

A Strong Correlation Between Pleural Fluid and Serum C-Reactive Protein Levels Across a Spectrum of Pleural Effusions.

Journal of clinical medicine research·2026
Same author

Rapid, intense pericholedochal fibrosis after preoperative biliary drainage: A prospective histologic study in pancreatoduodenectomy specimens.

Annals of hepato-biliary-pancreatic surgery·2026
Same author

Investigation of the Prevalence of Associated Genetic Mutations (Co-Mutations) in Patients with Actionable Driver Mutations in Lung Cancer: A Retrospective Study.

Diagnostics (Basel, Switzerland)·2026
Same author

Deep learning on histopathological images to predict breast cancer recurrence risk and chemotherapy benefit: a multicentre, model development and validation study.

The Lancet. Oncology·2026
Same author

Postoperative spindle cell nodule of the urethra and bladder in a 90-year-old male: A diagnostic challenge.

Central European journal of urology·2026
Same journal

Edaravone Dexborneol regulates the endothelial PPARγ-PON1 axis to inhibit high-cholesterol-induced atherosclerosis.

Clinical science (London, England : 1979)·2026
Same journal

HDAC9 promotes atherosclerosis by suppressing CYP7A1 and impairing hepatic cholesterol excretion.

Clinical science (London, England : 1979)·2026
Same journal

Clusterin ameliorates LPS-induced ARDS by inhibiting the Wnt/β-catenin pathway.

Clinical science (London, England : 1979)·2026
Same journal

Human cytomegalovirus at the maternal-fetal interface: an overview of pathogenesis, defence, and interventions.

Clinical science (London, England : 1979)·2026
Same journal

Cardiometabolic regulation by adipocyte-derived leptin and the brain melanocortin system.

Clinical science (London, England : 1979)·2026
Same journal

Impact of impaired branched-chain amino acid metabolism on kidney disease.

Clinical science (London, England : 1979)·2026
See all related articles

Cardiovascular reactivity (CVR) patterns can now be identified for specific diseases. This study developed methods to detect disease-specific CVR in familial Mediterranean fever (FMF) patients, aiding diagnosis and understanding autonomic function.

Area of Science:

  • Autonomic Nervous System
  • Cardiovascular Physiology
  • Disease Biomarkers

Background:

  • Cardiovascular reactivity (CVR) reflects autonomic function but lacks specificity for individual disorders.
  • Recent findings suggest a CVR pattern unique to chronic fatigue syndrome.
  • Developing methods for disease-specific CVR assessment is crucial for clinical application.

Purpose of the Study:

  • To develop and validate methodologies for assessing disease-specific cardiovascular reactivity (CVR) patterns.
  • To prototype these methods using a cohort of familial Mediterranean fever (FMF) patients.
  • To evaluate the sensitivity and specificity of the developed CVR assessment techniques.

Main Methods:

  • A 10-minute supine and 30-minute head-up tilt test was performed on 50 FMF patients and control groups.

Related Experiment Videos

  • Recordings included beat-to-beat heart rate, blood pressure, and pulse transit time.
  • Data analysis involved statistical identification of CVR predictors, computation of discriminant scores (DS), and fractal/recurrence quantitative analysis.

    • Main Results:

    • Abnormal CVR patterns were consistently observed in FMF patients across five different methodological studies.
    • The most accurate method, utilizing beat-to-beat heart rate and pulse transit time, achieved 88% sensitivity and 90.1% specificity for FMF.
    • Disease-specific CVR patterns were successfully identified using the developed methodologies.

    Conclusions:

    • The study successfully developed methodologies capable of identifying disease-specific CVR patterns.
    • Disease-specific CVR in FMF may result from interactions between FMF-specific neuroendocrine loops and cardiovascular homeostatic mechanisms.
    • Recognizing disease-specific CVR patterns holds potential for advancing the understanding of homeostatic mechanisms and clinical practice.