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Cell interactions with laser-modified polymer surfaces.

M D Ball1, R Sherlock, T Glynn

  • 1National Centre for Biomedical Engineering Science, National University of Ireland, Galway, Galway, Ireland. michael.ball@nuigalway.ie

Journal of Materials Science. Materials in Medicine
|August 31, 2004
PubMed
Summary
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Excimer laser treatment enhanced nylon 12 surface wettability, improving initial cell proliferation. However, long-term cell activity decreased on treated surfaces, indicating potential limitations for biomaterial applications.

Area of Science:

  • Biomaterials Science
  • Surface Chemistry
  • Cell Biology

Background:

  • Polymeric biomaterial performance relies on both bulk and surface properties.
  • Surface property modification is crucial for controlling cell and protein interactions.
  • Existing methods may compromise surface suitability for bulk property optimization.

Purpose of the Study:

  • To investigate the use of excimer laser treatment for modifying nylon 12 surface properties.
  • To assess the impact of laser-induced surface changes on cell behavior.
  • To evaluate the long-term efficacy of treated nylon 12 for cell interactions.

Main Methods:

  • Nylon 12 surfaces were modified using short-wavelength UV excimer laser treatment.
  • Surface wettability was quantified using contact angle measurements.

Related Experiment Videos

  • Cell morphology, activity, and proliferation were assessed using 3T3 fibroblasts and HUVEC cells, and confocal laser scanning microscopy (CLSM).

    • Main Results:

    • Excimer laser treatment reproducibly altered nylon 12 surface structure and wettability.
    • Both fibroblast and endothelial cells showed improved initial proliferation on treated surfaces.
    • Over seven days, cell activity declined on both control and treated surfaces, with a notable decrease in endothelial cell activity and number on the treated polymer.

    Conclusions:

    • Excimer laser modification offers a rapid, cost-effective method to alter polymer surface wettability.
    • While initially promoting cell proliferation, the long-term effects on cell activity require further investigation for biomaterial development.
    • Surface reorganisation and oxygen incorporation are key mechanisms driving the observed changes.