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Urinary calculi: bacteriological and chemical association
1Department of Medical Microbiology and Immunology, Faculty of Medicine, Al-Fateh University, Tripoli, Libyan Arab Jamahiriya.
Summary
Urinary tract infections (UTIs) are common in urolithiasis patients. Urine cultures accurately identify most bacteria causing urinary stones and associated UTIs, aiding treatment decisions.
Area of Science:
- Urology
- Microbiology
- Biochemistry
Background:
- Urinary tract infections (UTIs) are frequently associated with urolithiasis (urinary stone formation).
- Understanding the bacteriology of urinary calculi is crucial for effective management of UTIs and stone disease.
- The relationship between infection, stone composition, and antibiotic resistance requires further investigation.
Purpose of the Study:
- To investigate the bacteriology of urinary calculi in patients with urolithiasis.
- To correlate findings with urinary tract infection, stone formation, chemical composition, and antibiotic sensitivity.
- To determine the diagnostic utility of urine cultures in identifying stone-associated bacteria.
Main Methods:
- Studied 52 patients with urolithiasis, collecting urine, serum, and urinary calculi specimens.
- Performed serum biochemical tests for uric acid, calcium, and phosphorus.
- Conducted urine analysis and culture, and analyzed bacterial isolates from urine and calculi for antibiotic susceptibility.
Main Results:
- 19 out of 52 patients (37%) had associated urinary tract infections.
- Escherichia coli and Proteus mirabilis were the most common causative microorganisms.
- Bacterial isolates from urine and calculi exhibited different antimicrobial susceptibility patterns.
Conclusions:
- Urine culture can detect infecting organisms in over 50% of urolithiasis patients.
- Identifying bacteria in urine and calculi is essential for targeted antibiotic therapy.
- Bacteriology of urinary calculi plays a significant role in stone formation and treatment outcomes.