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Recurrent respiratory papillomatosis in a survivor of extreme prematurity

S L Lee1, Y Hui

  • 1Department of Paediatrics and Adolescent Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China.

Pediatric Pulmonology
|August 31, 2004
PubMed

Insights

Recurrent respiratory papillomatosis (RRP) is a rare childhood disease. This case study shows premature infants can have a good prognosis despite RRP diagnosis, challenging previous assumptions.

Area of Science:

  • Pediatrics
  • Otolaryngology
  • Genetics

Background:

  • Recurrent respiratory papillomatosis (RRP) is a rare pediatric airway disease.
  • Prematurity and early presentation are considered poor prognostic indicators for RRP.
  • RRP is caused by the human papillomavirus (HPV).

Observation:

  • A 24-week premature infant presented with stridor, weak cry, and hoarseness at 9 months corrected age.
  • Diagnosis of RRP was delayed until 21 months corrected age.
  • The infant underwent laser excision for RRP.

Findings:

  • The premature infant survived RRP and laser treatment, reaching 2.5 years of age.
  • This case suggests RRP prognosis in premature infants may not be uniformly poor.
  • Early diagnosis and intervention are crucial for managing RRP in high-risk infants.

Implications:

  • RRP should be considered in the differential diagnosis of airway issues in extremely premature infants.
  • This case challenges the established notion of poor prognosis for RRP in premature infants.
  • Further research is needed to understand RRP outcomes in the premature population.

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