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Microarray analysis of postmortem temporal cortex from patients with schizophrenia.

Christopher Aston1, Lixin Jiang, Boris P Sokolov

  • 1Neuroscience Discovery Research, Wyeth Research, Princeton, New Jersey, USA.

Journal of Neuroscience Research
|August 31, 2004
PubMed
Summary
This summary is machine-generated.

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Schizophrenia is linked to reduced expression of myelin-related genes and altered neurodevelopmental and circadian rhythm genes, suggesting oligodendroglial and epigenetic roles in the disorder.

Area of Science:

  • Neuroscience
  • Genetics
  • Molecular Biology

Background:

  • Schizophrenia is a complex psychiatric disorder with poorly understood molecular underpinnings.
  • Previous research suggests potential involvement of genetic and environmental factors.

Purpose of the Study:

  • To investigate molecular mechanisms and gene expression changes in the brain associated with schizophrenia.
  • To identify specific genes and pathways implicated in the pathophysiology of schizophrenia.

Main Methods:

  • Gene expression profiling of approximately 12,000 genes in the middle temporal gyrus.
  • Comparison between 12 subjects with schizophrenia and 14 matched healthy controls.

Main Results:

  • Significant decreases in expression of myelination-related genes (e.g., MAG, PLP1) were observed in schizophrenia subjects.

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  • Altered expression of genes involved in neurodevelopment, circadian rhythms (PER1), chromatin regulation, and signaling pathways were identified.

    • Conclusions:

    • Findings support the hypothesis of oligodendroglial abnormalities in schizophrenia.
    • Initial evidence suggests a role for epigenetic mechanisms and disrupted circadian rhythms in schizophrenia pathogenesis.