Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Limiting circulatory arrest using regional low flow perfusion.

Vicki D Kilpack1, Stephen A Stayer, E Dean McKenzie

  • 1Texas Children's Hospital and Baylor College of Medicine, Congenital Heart Surgery, and Pediatric Cardiovascular Anesthesiology, Houston, Texas 77030, USA. vdkilpac@texaschildrenshospital.org

The Journal of Extra-Corporeal Technology
|September 1, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Contemporary Approach to Vascular Rings.

The Annals of thoracic surgery·2026
Same author

Frequency of non-cardiac surgical procedures in neonates undergoing cardiac surgery: potential use of setting family and care team expectations.

Cardiology in the young·2026
Same author

Factors Influencing Operating Room Extubation of Adults With Congenital Heart Disease Undergoing Cardiac Surgery: A Single-Center Experience.

Journal of cardiothoracic and vascular anesthesia·2026
Same author

Pulmonary Atresia With Intact Ventricular Septum: Expert Review of the Surgical Management.

Seminars in thoracic and cardiovascular surgery. Pediatric cardiac surgery annual·2026
Same author

Longitudinal Cardiac Magnetic Resonance Imaging Demonstrates Differential Pulmonary Artery Growth in Patients with Bilateral Bidirectional Glenn Circulations.

Pediatric cardiology·2026
Same author

Contemporary Use of Circulatory Arrest and Selective Antegrade Cerebral Perfusion During Neonatal Aortic Arch Surgery-International Survey.

The Annals of thoracic surgery·2026
Same journal

Corrigendum to: High pressure excursion in a radial design oxygenator.

The journal of extra-corporeal technology·2026
Same journal

Understanding pressure excursions in extracorporeal technologies: The role of shear stress and hematologic predisposition.

The journal of extra-corporeal technology·2026
Same journal

Toward standardized guidelines for distal perfusion cannulae in V-A ECMO and ECPELLA: timing, sizing, monitoring, and management.

The journal of extra-corporeal technology·2026
Same journal

Ventricular assist device simulation to improve staff confidence and knowledge when caring for patients supported with the Berlin heart☆.

The journal of extra-corporeal technology·2026
Same journal

Strategic decision-making for redo cardiac surgical patients with biventricular heart failure - description of a surgical technique.

The journal of extra-corporeal technology·2026
Same journal

Learning from a pitfall: Atrial septostomy in LV failure under VA-ECMO for pulmonary hypertension.

The journal of extra-corporeal technology·2026
See all related articles

Regional low flow perfusion may reduce neurologic risks in neonatal cardiac surgery by limiting deep hypothermic circulatory arrest. This technique shows promise for improved patient outcomes during complex procedures.

Area of Science:

  • Cardiology
  • Pediatric Surgery
  • Neurology

Background:

  • Deep hypothermic circulatory arrest (DHCA) is standard in neonatal cardiac surgery but linked to neurologic issues.
  • Procedures like the Norwood operation and aortic arch advancement often necessitate DHCA.

Purpose of the Study:

  • To evaluate the efficacy of regional low flow perfusion (RLFP) in minimizing DHCA during neonatal cardiac surgery.
  • To assess patient outcomes and safety when using RLFP for cerebral protection.

Main Methods:

  • 34 neonates undergoing aortic arch reconstruction or Norwood procedure with RLFP.
  • Monitored cerebral saturation (NIRS) and blood flow velocity (TCD).
  • Utilized dual arterial pressure monitoring and point-of-care blood gas analysis.

Related Experiment Videos

Main Results:

  • Mean bypass time was 180 min, with a mean DHCA time of 19 min and RLFP time of 50 min.
  • Patient clinical data remained consistent despite lower flow rates.
  • Achieved a 30-day postoperative mortality rate of 2.9% with no reported neurologic injury.

Conclusions:

  • Regional low flow cerebral perfusion appears beneficial in reducing DHCA duration in neonatal cardiac surgery.
  • Further research is needed to compare RLFP directly with DHCA for long-term patient outcomes.