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Updated: Aug 22, 2026
A Revised Method for Inducing Secondary Lymphedema in the Hindlimb of Mice
Published on: November 2, 2019
[Metabolism of hyaluronic acid and extremity lymphedema]
Ning-fei Liu1, Lu-rong Zhang, Sheng-li Li
1The Department of Plastic and Reconstructive Surgery, Ninth People's Hospital, Shanghai Institute of Plastic Surgery, Shanghai 200011, China.
Objective:
To investigate the possible influence of the impairment of lymph fluid on the metabolism of hyaluronic acid (HA) in the lymphedematous skin tissue.
Methods:
Tissue fluid was collected in lymphedematous limbs and the contralateral healthy limbs of 39 patients and HA content was measured with radioimmunoassay. The protein contents were also measured.
Results:
The HA contents in interstitial fluid of lymphedematous limb were significantly (8 fold) higher than that of normal limb. The protein concentration in the tissue fluid did not show significant differences between lymphedema and those with normal tissue.
Conclusion:
The result suggests blockage of regional draining lymphatics may impairs breakdown of HA and the stagnation of HA in the limb may exert a deleterious effect on the interstitium.
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