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Related Experiment Videos

Short-term brain atrophy changes in relapsing-remitting multiple sclerosis.

Robert Zivadinov1, Francesca Bagnato, Davide Nasuelli

  • 1Department of Clinical Medicine and Neurology, University of Trieste, Trieste, Italy. rzivadinov@thejni.org

Journal of the Neurological Sciences
|September 1, 2004
PubMed
Summary
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A 3-month interval is insufficient to detect brain atrophy in relapsing-remitting multiple sclerosis (RRMS). Ring-enhancing lesions may indicate more severe brain tissue loss, but gadolinium enhancement duration does not predict short-term brain volume changes.

Area of Science:

  • Neuroimaging
  • Neurology
  • Radiology

Background:

  • Relapsing-remitting multiple sclerosis (RRMS) is characterized by unpredictable neurological relapses.
  • Monitoring disease progression, particularly brain atrophy, is crucial for managing RRMS.
  • The utility of short-term intervals and specific MRI findings in detecting these changes requires further investigation.

Purpose of the Study:

  • To determine if a 3-month interval is sufficient to detect whole-brain atrophy in RRMS patients.
  • To assess the predictive value of monthly gadolinium (Gd)-enhanced MRI and enhancement patterns for brain atrophy.
  • To investigate the relationship between Gd-enhancement and brain parenchymal fraction (BPF) changes.

Main Methods:

  • Thirty RRMS patients underwent monthly clinical and MRI assessments over 3 months.

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  • Brain parenchymal fraction (BPF) changes were calculated using semiautomated and automated segmentation methods (Trieste, Buffalo, SPM99).
  • Gd-enhancement patterns, including ring-enhancement, were analyzed in relation to BPF and clinical outcomes.

    • Main Results:

    • No significant BPF changes were detected across any of the three methods at any time point over the 3-month study period.
    • A slight, non-significant decrease in BPF was observed from baseline to month 3.
    • In patients with ring-enhancement, significant differences in BPF, EDSS, and relapse number changes were noted between baseline and month 3.

    Conclusions:

    • A 3-month observation period is inadequate for detecting significant brain atrophy progression in RRMS.
    • Ring-enhancement patterns may be associated with more substantial short-term brain tissue loss.
    • Short-term Gd-enhancement activity and duration do not correlate with brain volume changes in RRMS.