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Updated: Aug 22, 2026

Transthoracic Echocardiography in Mice
Published on: May 28, 2010
Cardiac granulocytic sarcoma (chloroma): in vivo diagnosis with transesophageal echocardiography
Pedro Marcos-Alberca1, Borja Ibáñez, Manuel Rey
1Department of Cardiology, Fundación Jiménez Díaz, Madrid, Spain. marcosal@arrakis.es
Insights
Granulocytic sarcoma, a rare acute leukemia complication, can affect the heart. Transesophageal echocardiography is crucial for diagnosing this rare cardiac involvement in vivo.
Area of Science:
- Hematology
- Cardiology
- Oncology
Background:
- Granulocytic sarcoma (chloroma) is an extramedullary manifestation of acute myeloid leukemia.
- Cardiac involvement by granulocytic sarcoma is exceptionally rare, often discovered post-mortem.
Observation:
- This case highlights the diagnostic utility of transesophageal echocardiography (TEE) for in vivo detection of cardiac granulocytic sarcoma.
- Specific imaging features indicative of cardiac granulocytic sarcoma via TEE are detailed.
Findings:
- TEE provides detailed visualization of cardiac masses and their characteristics.
- The study describes the key echocardiographic findings associated with granulocytic sarcoma in the heart.
Implications:
- Early in vivo diagnosis of cardiac granulocytic sarcoma using TEE can potentially alter patient management.
- This case underscores the importance of considering rare presentations of leukemia, even in cardiac structures.
Abstract:
Granulocytic sarcoma, or chloroma, is an uncommon presentation of acute leukemia. Cardiac involvement is very rare and usually diagnosed at autopsy. We present a case that discloses the essential role of transesophageal echocardiography for its in vivo diagnosis. The principal features with this imaging technique are finely described.
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