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Invasive superficial spreading melanomas arising from clinically normal skin
Nancy E Thomas1, Pamela Groben
1Department of Dermatology, University of North Carolina at Chapel Hill, NC 27599, USA. nthomas@med.unc.edu
Journal of the American Academy of Dermatology
|September 1, 2004
Summary
This study documents three invasive melanomas that developed on normal skin without prior moles. These "de novo" melanomas were small and difficult to diagnose clinically.
Area of Science:
- Dermatology
- Oncology
- Pathology
Background:
- Superficial spreading melanoma is the most common subtype of invasive melanoma.
- Melanomas can arise de novo from clinically normal skin or from pre-existing melanocytic nevi.
- Early diagnosis of melanoma is crucial for patient survival.
Observation:
- This report details three cases of invasive superficial spreading melanoma.
- These melanomas originated on clinically normal skin, lacking association with a nevus.
- The melanomas were invasive at a small diameter and presented few diagnostic criteria.
Findings:
- Histologic examination revealed no nevus association in these invasive melanomas.
- Clinical and dermoscopic features were subtle, complicating early diagnosis.
- Pathologic correlation confirmed the de novo origin and invasive nature.
Implications:
- Highlights the occurrence of de novo invasive melanomas on normal skin.
- Emphasizes the diagnostic challenges posed by small, subtle melanomas.
- Suggests the need for heightened clinical vigilance for suspicious lesions, even without nevus association.