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Updated: Aug 22, 2026

Deriving the Time Course of Glutamate Clearance with a Deconvolution Analysis of Astrocytic Transporter Currents
Published on: August 7, 2013
Reversal or reduction of glutamate and GABA transport in CNS pathology and therapy
Nicola J Allen1, Ragnhildur Káradóttir, David Attwell
1Department of Physiology, University College London, Gower Street, London, WC1E 6BT, UK.
Abstract:
A dysfunction of amino acid neurotransmitter transporters occurs in a number of central nervous system disorders, including stroke, epilepsy, cerebral palsy and amyotrophic lateral sclerosis. This dysfunction can comprise a reversal of transport direction, leading to the release of neurotransmitter into the extracellular space, or an alteration in transporter expression level. This review analyses the role of glutamate and GABA transporters in the pathogenesis and therapy of a number of acute and chronic neurological disorders.
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