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In Utero Electroporation of Multiaddressable Genome-Integrating Color (MAGIC) Markers to Individualize Cortical Mouse Astrocytes
Published on: May 21, 2020
Astrocytes go into presenter mode
Lara Labarta-Bajo1, Nicola J Allen2
1Molecular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Abstract:
Astrocytes are glial cells important for neuronal health, but their functions in CNS immunopathology are less understood. In a recent issue of Nature, Lee et al. report that CD40 engagement and proinflammatory cytokines promote lipid droplet accumulation in astrocytes and subsequent antigen presentation, boosting pathogenic CD4+ T cell responses during experimental autoimmune encephalomyelitis.
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