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Updated: Aug 22, 2026

A Comparative Approach for Quantitative Cell Counting Studies in Widely Different Mammalian Brains
Published on: January 16, 2026
Gender differences in cortical complexity
Eileen Luders1, Katherine L Narr, Paul M Thompson
1Laboratory of Neuroimaging, Department of Neurology, Brain Mapping Division, UCLA School of Medicine, 710 Westwood Plaza, 4238 Reed, Los Angeles, California 90095, USA.
Abstract:
Cortical complexity, a measure that quantifies the spatial frequency of gyrification and fissuration of the brain surface, has not been thoroughly characterized with respect to gender differences in the human brain. Using a new three-dimensional (3D) analytic technique with magnetic resonance imaging, we found greater gyrification in women than men in frontal and parietal regions. Increased complexity implies more cortical surface area, which may offset gender differences in brain volume and account for behavioral gender differences.
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