Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Allergen immunotherapy.

Jennifer L Huggins1, R John Looney

  • 1University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA. Jennifer_Huggins@urmc.rochester.edu

American Family Physician
|September 2, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Gut microbial IgA coating in infants with traditional farming lifestyle and urban infants with allergic outcomes.

Frontiers in immunology·2026
Same author

Update on allergen immunotherapy for asthma.

Current opinion in pulmonary medicine·2026
Same author

Farm exposure in infancy is associated with elevated systemic IgG<sub>4</sub>, mucosal IgA responses, and lower incidence of food allergy.

Science translational medicine·2025
Same author

A Phenotypically Distinct Human Th2 Cell Subpopulation Is Associated With Development of Allergic Disorders in Infancy.

Allergy·2025
Same author

Treatment and Visual Outcomes in Pediatric Patients with Autosomal Dominant Neovascular Inflammatory Vitreoretinopathy: A Cohort Study.

Ocular immunology and inflammation·2024
Same author

Human milk antibodies to global pathogens reveal geographic and interindividual variations in IgA and IgG.

The Journal of clinical investigation·2024

Allergen immunotherapy (allergy vaccine therapy) reduces allergic reactions by gradually increasing allergen doses. This safe treatment is effective for insect sting allergies, allergic rhinitis, and asthma, potentially altering the disease course.

Area of Science:

  • Immunology
  • Allergy and Clinical Immunology

Background:

  • Allergen immunotherapy (AIT) involves administering increasing allergen doses to desensitize patients with IgE-mediated conditions.
  • AIT aims to reduce short-term symptom severity and long-term inflammatory responses, preventing persistent allergic disease.

Purpose of the Study:

  • To summarize the principles, applications, and safety considerations of allergen immunotherapy.
  • To highlight AIT's efficacy in specific allergic conditions and contraindications for others.

Main Methods:

  • Administration of gradually increasing quantities of specific allergens.
  • Mandatory observation period post-injection for anaphylaxis monitoring.
  • Exclusion of patients on beta-adrenergic blockers due to potential masking of anaphylaxis symptoms.

Related Experiment Videos

Main Results:

  • AIT is effective for stinging-insect hypersensitivity, allergic rhinitis/conjunctivitis, and allergic asthma.
  • AIT is not effective for atopic dermatitis, urticaria, or headaches.
  • AIT is potentially dangerous for food or antibiotic allergies and requires immediate anaphylaxis management capability.

Conclusions:

  • Allergen immunotherapy offers a potentially disease-modifying treatment for specific allergic conditions.
  • Safe administration requires strict protocols, including professional supervision and patient monitoring.
  • Unlike symptomatic treatments, AIT can alter the long-term course of allergic disease after 3-5 years.