Related Experiment Video
Updated: Aug 11, 2026

Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates
Published on: March 20, 2015
Recognition and stabilization of peptide alpha-helices using templatable nanoparticle receptors
Ayush Verma1, Hiroshi Nakade, Joseph M Simard
1Department of Chemistry, University of Massachusetts, Amherst, MA 01003, USA.
Abstract:
alpha-Helices are important structural elements in proteins. To provide a scaffold for the facial recognition of peptides, we have explored the interaction of cationic mixed monolayer protected clusters (MMPCs) with a tetra-aspartate peptide in water. In these studies, substantial enhancement of peptide helicity was observed upon addition of the MMPC. Significantly, this stabilization increased with time, demonstrating templation of the monolayer to the peptide helix.

