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An Experimental Model of Diet-Induced Metabolic Syndrome in Rabbit: Methodological Considerations, Development, and Assessment
Published on: April 20, 2018
[Influence of single leaf Asarum himalaicum on renal function of rabbits]
Hai-Xia Ming1, Jia-Jun Liu, Shi-Zuo Huang
1Department of Physiology, Gansu College of Traditional Chinese Medicine, Lanzhou, Gansu Province 730000, China. zhh2004222@sina.com
Objective:
To study the influence of single leaf Asarum himalaicum on the renal function of rabbits.
Methods:
Rabbits were divided into three groups. Asarum himalaicum, Asarum heterotropoides and normal saline were intravenously administered to the rabbits of one group respectively. The urine volume per minute, urine pH, urine glucose, protein and red blood cells, BUN, SCr, TXB2, 6-keto-PGF1alpha, TXB2/6-keto-PGF1alpha, endothelin, p-aminohippuric acid clearance rate and phenolsulfonphthalein excretion rate were tested before and after the administration.
Results:
A certain dosage of single leaf Asarum himalaicum caused acute renal failure in rabbits. The indices tested were significantly different between rabbits administered Asarum himalaicum and normal saline. As compared with the rabbits administered Asarum heterotropoides, the results of indices tested decreased, but without statistical significance, except for SCr.
Conclusion:
The single leaf Asarum himalaicum can cause renal damage to rabbits. Its renal toxicity is lower that that of Asarum heterotropoides.
