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Updated: Aug 22, 2026
Quantification of Neurovascular Protection Following Repetitive Hypoxic Preconditioning and Transient Middle Cerebral Artery Occlusion in Mice
Published on: May 4, 2015
[Preventive effect of Breviscapus Injection on chronic hypoxic myocardium injury in rats]
Sun-Zhong Mao1, Zhe Yan, Yu-Peng Xie
1Department of Biochemistry, Wenzhou Medical College, Wenzhou, Zhejiang Province 325027, China. lmao@wzmc.com
Objective:
To study the preventive effect of Breviscapus Injection on the chronic hypoxic myocardium injury in rats and its mechanism.
Methods:
Transmission electron microscope and biochemical analysis were used to assay the therapeutic effect of Breviscapus Injection in rat model induced by 4 week's hypoxia.
Results:
The contents of malondialdehyde (MDA) and Ca(2+) in the homogenate of myocardial tissue of the hypoxic rats were significantly higher than those of the control rats. The activities of superoxide dismutase (SOD), nitric oxide synthase (NOS) in the homogenate of myocardial tissue and the plasmic NO levels of the hypoxic rats were significantly lower than those of the control rats. Breviscapus Injection reduced the contents of MDA and Ca(2+), and increased the levels of SOD, NOS and NO. Ultrastructural examination revealed that the injuries of the ultrastructure of heart in hypoxic rats were improved by treatment with Breviscapus Injection.
Conclusion:
Breviscapus Injection can effectively prevent and treat the hypoxia-induced myocardial damage. One of its mechanisms may relate to its adjusting NO level, anti-damaging of free radicals and inhibiting calcium overload.
