Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Changes in connectivity profiles define functionally distinct regions in human medial frontal cortex.

H Johansen-Berg1, T E J Behrens, M D Robson

  • 1Oxford Centre for Functional Magnetic Resonance Imaging of the Brain, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom. heidi@fmrib.ox.ac.uk

Proceedings of the National Academy of Sciences of the United States of America
|September 2, 2004
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Activation of TREK-1 and TREK-2 Two-Pore Domain Potassium Channels by the K<sub>v</sub>4 Channel Modulator, NS5806.

Pharmacology research & perspectives·2026
Same author

Implicit learning across varying temporal scales in individuals with and without mood instability.

Journal of affective disorders·2025
Same author

Brain Charts for the Rhesus Macaque Lifespan.

bioRxiv : the preprint server for biology·2024
Same author

The effect of a one-year vigorous physical activity intervention on fitness, cognitive performance and mental health in young adolescents: the Fit to Study cluster randomised controlled trial.

The international journal of behavioral nutrition and physical activity·2021
Same author

Effects of a programme of vigorous physical activity during secondary school physical education on academic performance, fitness, cognition, mental health and the brain of adolescents (Fit to Study): study protocol for a cluster-randomised trial.

Trials·2019
Same author

Lipoprotein markers associated with disability from multiple sclerosis.

Scientific reports·2018

Neuroscience research reveals how brain structure relates to function using advanced MRI. This study maps brain regions by connectivity, identifying distinct areas like the supplementary motor area (SMA) and pre-SMA.

Area of Science:

  • Neuroscience
  • Brain Imaging
  • Cognitive Neuroscience

Background:

  • Understanding the relationship between brain structure and function is a core challenge in neuroscience.
  • Traditional anatomical landmarks poorly correlate with microstructural boundaries, and cytoarchitecture is not visible in living brains during functional studies.

Purpose of the Study:

  • To directly investigate structure-function relationships in the brain using non-invasive imaging techniques.
  • To define distinct neocortical regions based on connectivity profiles and identify borders where these profiles change.

Main Methods:

  • Utilized diffusion-weighted magnetic resonance imaging (dMRI) and functional magnetic resonance imaging (fMRI) in living subjects.
  • Defined brain regions as volumes with similar connectivity patterns, identifying borders by abrupt changes in connectivity profiles.

Related Experiment Videos

  • Correlated connectivity-defined regions with brain areas activated during tasks specifically engaging the supplementary motor area (SMA) and pre-SMA.

    • Main Results:

    • Identified a distinct border between the supplementary motor area (SMA) and pre-supplementary motor area (pre-SMA) based solely on connectivity profiles, matching expected anatomical locations.
    • Demonstrated that the connectivity patterns of the identified SMA and pre-SMA regions corresponded with motor and prefrontal areas, respectively.
    • Found strong spatial correlations between regions defined by connectivity and those activated during selective SMA and pre-SMA tasks.

    Conclusions:

    • Established a strong link between brain structure (defined by connectivity) and function (defined by task-based activation) in the medial frontal cortex.
    • Validated a novel strategy using connectivity mapping to delineate functionally distinct brain regions and test structure-function correspondences in other brain areas.