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Published on: October 12, 2018
HIV-1 inhibitory compounds from Calophyllum brasiliense leaves
Maira Huerta-Reyes1, Maria Del Carmen Basualdo, Fumiko Abe
1Department of Natural Products, Institute of Chemistry, National University of Mexico, Ciudad Universitaria, 04510, Mexico D. F., Mexico.
Abstract:
The hexane, acetone and methanol extracts of Calophyllum brasiliense leaves were fractionated following a three bioassay guide: high HIV-1 RT inhibition, low cytotoxicity on MT2 cells and high inhibition of HIV-1 IIIb/LAV replication. This led to the isolation of three anti HIV-1 dipyranocoumarins: calanolides A and B and soulattrolide. In contrast, other isolated compounds such as apetalic acid, isoapetalic acid, a structural isomer of isoapetalic acid, friedelin, canophyllol and amentoflavone were devoid of HIV-1 RT inhibitory activity. Calanolide C was also obtained as a natural product and showed moderate inhibitory properties.
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