Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Technology platforms for pharmacogenomic diagnostic assays.

Walter H Koch1

  • 1Roche Molecular Systems, Pharmacogenetics Department, 4300 Hacienda Drive, Pleasanton, California 94588, USA. walter_h.koch@roche.com

Nature Reviews. Drug Discovery
|September 2, 2004
PubMed
Summary

New molecular diagnostic assays leverage genomic variation and multiplex technologies to personalize medicine. These tests guide treatment by identifying disease subtypes, optimal drugs, and patient risks for adverse drug reactions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Detection of T790M, the Acquired Resistance EGFR Mutation, by Tumor Biopsy versus Noninvasive Blood-Based Analyses.

Clinical cancer research : an official journal of the American Association for Cancer Research·2015
Same author

Co-development of a companion diagnostic for targeted cancer therapy.

New biotechnology·2012
Same author

Clinical applications of microarray-based diagnostic tests.

BioTechniques·2005
Same author

The External RNA Controls Consortium: a progress report.

Nature methods·2005
Same author

Polymorphic variations in GSTM1, GSTT1, PgP, CYP2D6, CYP3A5, and dopamine D2 and D3 receptors and their association with tardive dyskinesia in severe mental illness.

Journal of clinical psychopharmacology·2005
Same author

Making sense of DNA microarray data.

Methods in molecular medicine·2005

Area of Science:

  • Genomics
  • Molecular Diagnostics
  • Pharmacogenomics

Background:

  • Genomic variations significantly impact individual drug responses.
  • Multiplex assay technologies have advanced rapidly.
  • In vitro diagnostic assays are evolving to incorporate these advances.

Purpose of the Study:

  • To review the strengths and limitations of current technologies for molecular diagnostic assays.
  • To highlight the role of these assays in guiding therapeutic treatment.
  • To discuss the application of genomic variation in personalized medicine.

Main Methods:

  • Review of existing literature on multiplex assay technologies.
  • Analysis of platforms used for in vitro diagnostics.
  • Evaluation of genomic variation data relevant to drug response.

Related Experiment Videos

Main Results:

  • Genomic understanding and multiplex assays are converging for novel diagnostic applications.
  • Molecular diagnostics will inform treatment decisions for various diseases.
  • These assays predict drug efficacy and identify patients at risk of adverse reactions.

Conclusions:

  • Molecular diagnostic assays are crucial for personalized therapeutic strategies.
  • The integration of genomic data enhances treatment precision.
  • Continued development of assay technologies will improve patient outcomes.