Cancer chromosomes in crisis
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Updated: Aug 3, 2026
07:42
Chromosome Preparation From Cultured Cells
Published on: January 28, 2014
Nature Genetics
|September 2, 2004
Abstract:
The benign-to-malignant transition in human breast cancer is associated with a marked increase in chromosomal aberrations. A new study suggests that telomere dysfunction and its associated bridge-fusion-breakage cycles may drive this episodic instability, thereby providing aspiring cancer cells with the multiple genetic aberrations needed to achieve a fully malignant state.
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