Related Experiment Video
Updated: Aug 22, 2026

Inspiratory Muscle Training as an Adjunct to the Treatment of Weaning Failure in Critically Ill Patients: A Practical Guide
Published on: January 30, 2026
[Effect of aminophylline on fatigue of inspiratory muscles]
Abstract:
Effect of aminophylline on the fatigue of inspiratory muscles and ventilation disorders induced by respiratory resistive load was studied in cats. The administration of aminophylline on the background of inspiratory fatigue increases transdiaphragm pressure, restores bioelectric activity of inspiratory muscles and phrenic nerve, and decreases the respiratory duty cycle and rate. It is concluded that aminophylline in a dose of 24 mg/kg (i.v.) is capable of compensating the inspiratory muscle fatigue via both central and peripheral mechanisms, the latter effect being probably of greater importance.
Related Concept Videos
Antiasthma Drugs: Methylxanthines
Theophylline is thought to inhibit phosphodiesterase enzymes, increasing intracellular levels of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). This rise in cAMP and cGMP concentrations stimulates cardiac function,...
Skeletal Muscle Relaxants: Adverse Effects
Unlike...
Muscle Recovery and Fatigue
Nondepolarizing (Competitive) Neuromuscular Blockers: Pharmacological Actions
Although all competitive neuromuscular blockers are designed...
Adrenergic Agonists: Therapeutic Uses
Emergency and Intensive Care Unit (ICU) applications: Pressor agents increase blood pressure, heart rate, and contractility in shock and organ failure situations. Dopamine can induce vasodilation and stimulate adrenoceptors. Endogenous catecholamines are effective in treating cardiogenic shock. α2-agonists like clonidine can reverse anesthesia-induced hypertension.
Allergies and anaphylaxis:...
Adrenergic Agonists: Mixed-Action Agents
Ephedrine and pseudoephedrine lack a catecholamine group, making them less susceptible to degradation by metabolic enzymes. They have increased oral bioavailability and lipophilicity, resulting in a longer duration of action. Their response is reduced by...
