Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Inducible repression of CREB function disrupts amygdala-dependent memory.

S A Josselyn1, S Kida, A J Silva

  • 1Department of Neurobiology, Brain Research Institute, 695 Young Drive South, Gonda Building, UCLA, Los Angeles, CA 90095-1761, USA.

Neurobiology of Learning and Memory
|September 3, 2004
PubMed
Summary

The cAMP/Ca2+ responsive element binding protein (CREB) is crucial for long-term memory. This study confirms CREB-mediated transcription and protein synthesis are essential for conditioned taste aversion memory in mice.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Optimizing radish (Raphanus sativus L.) production through alternative nitrogen sources.

Brazilian journal of biology = Revista brasleira de biologia·2026
Same author

Microbiolization of Arachis hypogaea L. seeds.

Brazilian journal of biology = Revista brasleira de biologia·2026
Same author

Potassium silicate on the productivity of Opuntia stricta Haw and the infestation by Diaspis echinocacti.

Brazilian journal of biology = Revista brasleira de biologia·2025
Same author

The state of the art in Blue Amazon biodiversity: Protocol for a systematic review.

MethodsX·2025
Same author

Acute rapamycin treatment reveals novel mechanisms of behavioral, physiological, and functional dysfunction in a maternal inflammation mouse model of autism and sensory over-responsivity.

bioRxiv : the preprint server for biology·2024
Same author

Filter cake increases sugarcane yield.

Brazilian journal of biology = Revista brasleira de biologia·2023

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Behavioral Science

Background:

  • The cAMP/Ca2+ responsive element binding protein (CREB) family of transcription factors is implicated in long-term memory across various species.
  • Recent studies suggest performance deficits, not solely memory impairment, may result from CREB manipulation in mammals.

Purpose of the Study:

  • To elucidate the precise role of CREB in memory formation by employing a task with minimal performance demands.
  • To investigate the necessity of CREB-mediated transcription and protein synthesis for conditioned taste aversion memory.

Main Methods:

  • Utilized the conditioned taste aversion paradigm in mice, a task minimizing performance load.
  • Performed basolateral amygdala lesions and blocked protein synthesis to assess their impact on conditioned taste aversion.

Related Experiment Videos

  • Disrupted CREB function chronically and acutely in genetically modified mice to evaluate memory retention.

    • Main Results:

    • Lesioning or blocking protein synthesis in the basolateral amygdala significantly disrupted conditioned taste aversion.
    • Both chronic and acute disruption of CREB function in mice impaired conditioned taste aversion memory 24 hours post-training.
    • These results highlight the critical role of CREB in memory consolidation.

    Conclusions:

    • CREB-mediated transcription and protein synthesis are indispensable for the formation and retention of conditioned taste aversion memory.
    • The findings clarify CREB's role in memory, dissociating it from potential performance artifacts.
    • This research underscores the molecular mechanisms underlying associative learning and memory in mammals.