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Synthesis and evaluation of novel oxazoline MMP inhibitors
Gregory R Cook1, Ethirajan Manivannan, Thane Underdahl
1Center for Protease Research, Department of Chemistry, Biochemistry and Molecular Biology, North Dakota State University, Fargo, ND 58105, USA. gregory.cook@ndsu.nodak.edu
Bioorganic & Medicinal Chemistry Letters
|September 3, 2004
Abstract:
MMP inhibitors with novel oxazoline zinc binding groups have been synthesized and evaluated. Selectivity for the inhibition of MMP-9 over MMP-1, MMP-2, and MMP-12 has been achieved in several cases.
