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Autoantibodies to CD45 in systemic lupus erythematosus
J B Winfield1, T Mimura, P D Fernsten
1Division of Rheumatology and Immunology, University of North Carolina, Chapel Hill 27599.
International Journal of Clinical & Laboratory Research
|January 1, 1992
Abstract:
Autoantibodies to surface antigens on lymphocytes and other cells of the immune system may contribute to the development of immunoregulatory and other cellular immune abnormalities in patients with active systemic lupus erythematosus. Of special interest in this respect are autoantibodies to CD45 (leukocyte-common antigen, T200), a plasma membrane protein tyrosine phosphatase implicated in the regulation of lymphocyte functional activity, including cytotoxicity, proliferation, and differentiation.