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Targeting Therapy in Pediatric Inflammatory Bowel Disease
1Pediatric IBD Center, Cedars-Sinai Medical Center, 8635 West 3rd Street, Los Angeles, CA 90048 USA. Marla.Dubinsky@cshs.org
Current Treatment Options in Gastroenterology
|September 4, 2004
Summary
Advances in understanding the environment and immune system
Area of Science:
- Immunology
- Gastroenterology
- Pharmacology
Background:
- Inflammatory bowel disease (IBD) pathogenesis involves complex interactions between environmental factors and the immune system.
- Biotechnology advancements are driving new therapeutic strategies for IBD.
Purpose of the Study:
- To review current and emerging therapeutic agents for IBD.
- To highlight the relationship between IBD pathogenesis and therapeutic targets.
Main Methods:
- Review of scientific literature on IBD pathogenesis and therapeutics.
- Categorization of therapies into induction and maintenance strategies.
- Discussion of drug development focused on disease modification.
Main Results:
- IBD therapies range from broad-acting to specific cellular or cytokine targets.
- Therapeutic approaches include induction therapy for active disease and maintenance therapy for relapse prevention.
- Modern IBD drug development aims to modify disease progression and prevent complications.
Conclusions:
- Therapeutic selection for IBD patients should align with individual treatment goals.
- Emerging IBD therapies are increasingly focused on disease modification to alter the long-term course of illness.