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Updated: Aug 22, 2026
Fast and Specific Assessment of the Halogenating Peroxidase Activity in Leukocyte-enriched Blood Samples
Published on: July 28, 2016
Role of myeloperoxidase index in differentiation of megaloblastic and aplastic anemia
Jamal Eivazi Ziaei1, Saeed Dastgiri
1Hematology and Oncology Department, Imam Hospital, Tabriz, Iran. jziaei@hotmail.com
Background:
Elevated neutrophil myeloperoxidase may have a role in the diagnosis of megaloblastic erythropoiesis.
Aims:
To study the differentiating role of myeloperoxidase index in megaloblastic and aplastic anemia.
Settings And Design:
The myeloperoxidase index (MPXI) was studied in 96 patients with megaloblastic and aplastic anemia diagnosed on bone marrow aspiration and biopsy examinations.
Methods And Materials:
MPXI was measured with Technicon H1 (Bayer) automated analyzer. Nonparametric Mann-Whitney statistical test was used to compare the MPXI values between groups.
Results:
The mean MPXI in megaloblastics and aplastic anemia was 18.3 and 1.8 (p< 0.001) respectively. MPXI> 20 denoted megaloblastic and MPXI <-11.6 denoted aplastic anemia.
Conclusion:
MPXI measurement may assist differentiation of megaloblastic from aplastic anemia, while MPXI> 20 rules out aplastic and MPXI <-11.6 rules out megaloblastic anemia.
