Related Experiment Video
Updated: Feb 10, 2026

Author Spotlight: Optimizing Retinal Tissue Processing for Immunohistochemistry in Rabbit Models
Published on: November 10, 2023
A method of obtaining starting values of k(in) and k(out) for the indirect response models
Debu Mukherjee1, Matthew M Hutmacher
1System Inc., 659 Dunham Rd., Gurnee, IL 60031, USA. dmukherjee@statsystem.net
Abstract:
A method based on the multivariate technique known as principal component analysis is proposed to obtain starting values for the rate constants of indirect response models. The method is not iterative and only requires standard deviation calculations for two quantities, which are simple functions of the measured pharmacodynamic response. An algorithm is provided which can be implemented in a spreadsheet. The methodology is justified theoretically herein, nevertheless, two examples are provided to illustrate the method and demonstrate its viability.
Related Concept Videos
Microbial Growth Measurement: Indirect Methods
Methods of Obtaining Topography
Biodiversity and Human Values
Professional Values
The values that are the foundation of the nursing profession are altruism, autonomy, human dignity, and social justice.
First, altruism refers to the concern for the welfare and well-being of others without personal...
Critical Values
z Scores and Unusual Values
This score indicates how far a value is from the mean in terms of standard deviation. For example, if a data value has a z score of +1, the researcher can infer that the particular data value is one standard deviation above the mean. If another data...

