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Pigmented epidermal plaques in three dogs
Laura B Stokking1, Eugene J Ehrhart, Carol A Lichtensteiger
1Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois, Urbana, Illinois 61802, USA.
Journal of the American Animal Hospital Association
|September 7, 2004
Summary
Papillomavirus was detected in pigmented epidermal plaques (PEP) in three dogs. Treatment of underlying conditions and interferon-alpha helped two dogs, and one developed squamous cell carcinoma (SCC).
Area of Science:
- Veterinary Dermatology
- Canine Pathology
Background:
- Pigmented epidermal plaques (PEP) are uncommon skin lesions in dogs.
- The association between papillomavirus and PEP requires further investigation.
Observation:
- Papillomavirus was identified in PEP from three dogs: a miniature schnauzer, an American Staffordshire terrier, and a Pomeranian.
- Squamous cell carcinoma (SCC) developed within PEP in the Pomeranian.
- Two dogs showed clinical improvement with treatment of concurrent diseases and low-dose oral interferon-alpha.
Findings:
- This study reports papillomavirus-associated PEP in breeds previously undocumented for this condition.
- It highlights the potential for malignant transformation of PEP into SCC.
- Interferon-alpha may be beneficial in managing papillomavirus-associated PEP.
Implications:
- Early recognition and management of PEP are crucial due to the risk of malignant transformation.
- Further research into papillomavirus's role in canine dermatoses is warranted.
- This finding expands the known breed distribution for canine PEP.