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Related Experiment Videos

Processing and properties of two different poly (ortho esters).

M Kellomäki1, J Heller, P Törmälä

  • 1Institute of Biomaterials, Tampere University of Technology, P.O. Box 589, 33101 Tampere, Finland.

Journal of Materials Science. Materials in Medicine
|September 7, 2004
PubMed
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Two novel poly(ortho esters) (POEs) were processed and tested for in vitro degradation and mechanical properties. Self-reinforcement significantly improved strength, but overall degradation was rapid, limiting storage time for bone fixation and tissue engineering applications.

Area of Science:

  • Polymer Science
  • Biomaterials Engineering
  • Materials Science

Background:

  • Poly(ortho esters) (POEs) are a class of biodegradable polymers with potential applications in biomedical fields.
  • Understanding the processing, properties, and in vitro behavior of novel POE structures is crucial for their development.

Purpose of the Study:

  • To compare the processing and in vitro behavior of two structurally distinct poly(ortho esters).
  • To evaluate the mechanical properties and degradation profiles of these POEs under various conditions.
  • To assess the suitability of these POEs for applications such as bone fixation and tissue engineering.

Main Methods:

  • Two POEs were synthesized: one a copolymer with polyacetal, the other with trans-cyclohexanedimethanol-dilactide.
  • Polymers were processed using ultrasonic molding and melt-extrusion, with some undergoing self-reinforcement via die-drawing.

Related Experiment Videos

  • In vitro hydrolysis was conducted in phosphate buffer saline (PBS) and simulated body fluid (SBF) at 37°C, with mechanical testing and weight change analysis.

    • Main Results:

    • Self-reinforcing significantly increased shear strength, bending strength, and modulus in extruded rods.
    • In vitro degradation was faster in unchanged PBS compared to weekly changed PBS.
    • Strength retention varied from 14 to 42 days; dry weight decreased after the first week.
    • Crystallization occurred in SBF, while amorphous structures persisted in PBS; surface erosion was observed and processing-dependent.

    Conclusions:

    • Both POE types exhibited rapid in vitro degradation, with limited strength retention time.
    • Processing methods significantly influenced mechanical properties and erosion behavior.
    • Despite limitations in storage time, these POEs show promise for bone fixation and tissue engineering applications.