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Updated: Aug 5, 2026

Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids
Published on: April 25, 2016
Cortisol resistance in the New World revisited
Peter J Fuller1, Brian J Smith, Fraser M Rogerson
1Prince Henry's Institute of Medical Research, Clayton and Walter and Eliza Hall Institute, Parkville, Victoria, Australia. peter.fuller@phimr.monash.edu.au
Abstract:
Insights into the molecular basis of glucocorticoid action have been obtained from the analysis of cortisol resistance. The glucocorticoid receptor (GR) in both New World primates and guinea pigs has a decreased affinity, in vivo, for cortisol; this is achieved by two distinct mechanisms. In the New World primates recent studies have identified a key role for co-chaperones. The amino acids responsible for cortisol resistance in the guinea pig GR lie not in the ligand-binding pocket but on the surface of the receptor. We hypothesize that this region might be the site of interaction between the co-chaperones and the GR, and hence that the resistance occurs through the same mechanism, albeit from opposite sides.
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