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Related Experiment Videos

Seborrheic keratoses and cancer.

B Lindelöf1, B Sigurgeirsson, S Melander

  • 1Department of Dermatology, Karolinska Hospital, Stockholm, Sweden.

Journal of the American Academy of Dermatology
|June 1, 1992
PubMed
Summary
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The sign of Leser-Trélat, or eruptive seborrheic keratoses, is not a reliable indicator of internal malignancy. This study found no significant association between seborrheic keratoses and increased cancer risk.

Area of Science:

  • Dermatology and Oncology
  • Clinical Research

Background:

  • The sign of Leser-Trélat, characterized by the sudden eruption of seborrheic keratoses, is traditionally considered a marker for internal malignancy.
  • This association has been debated in clinical practice and research.

Purpose of the Study:

  • To investigate the potential association between malignant diseases and the sign of Leser-Trélat in a large cohort.
  • To evaluate the risk of internal cancer in patients presenting with eruptive seborrheic keratoses.

Main Methods:

  • A population-based study involving 1752 consecutive cases of seborrheic keratoses.
  • Utilized the Swedish Cancer Registry to assess malignancy diagnoses in relation to seborrheic keratosis diagnosis.
  • A case-control study was conducted to compare the prevalence of the sign of Leser-Trélat in cancer patients versus non-cancer controls.

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Main Results:

  • A slightly increased overall cancer risk was observed (relative risk = 1.2), primarily due to a higher incidence of cutaneous squamous cell carcinoma.
  • In patients with seborrheic keratoses and a malignancy diagnosed within one year, only a small proportion (6 out of 62) possibly presented with the sign of Leser-Trélat.
  • The prevalence of the sign of Leser-Trélat was similar in both cancer patients and age/sex-matched controls without cancer.

Conclusions:

  • The study provides no evidence to support the hypothesis that eruptive seborrheic keratoses are a reliable indicator of internal cancer risk.
  • The findings suggest that the sign of Leser-Trélat may not be a significant predictor of underlying malignancy.