Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Constitutive hyperdopaminergia is functionally associated with reduced behavioral lateralization.

Elise Morice1, Cécile Denis, Alessandro Macario

  • 1INSERM-U513, Neurobiologie et Psychiatrie, Créteil Cedex, France.

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
|September 9, 2004
PubMed
Summary

Hyperactivity in the dopamine system reduces behavioral lateralization in mice lacking the dopamine transporter (DAT) gene. This finding supports degree of lateralization as a phenotype for studying brain lateralization in health and disease.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Perceptions of Buprenorphine With Naloxone Treatment and the Fear of Precipitated Withdrawal: A Qualitative Exploration With HIV Prevention Trials Network 094 INTEGRA Participants and Staff.

Drug and alcohol review·2026
Same author

Prevalence of Illicit Drug Detection in 5 US Cities Among Out-of-Treatment People Who Inject Drugs.

JAMA network open·2026
Same author

"I Want to Live: A Qualitative Investigation of Barriers and Facilitators to ART Adherence & Mental Health Maintenance in People With HIV".

Journal of the International Association of Providers of AIDS Care·2026
Same author

Aluminium adjuvants and childhood health: a call for science.

Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)·2025
Same author

Excitatory glycine receptors control ventral hippocampus synaptic plasticity and anxiety-related behaviors.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

NF-κB-Mediated Upregulation of Tissue Factor Contributes to the Procoagulant Phenotype of Smooth Muscle Cells from Abdominal Aorta Aneurysm in Human.

Thrombosis and haemostasis·2025

Area of Science:

  • Neuroscience
  • Genetics
  • Behavioral Science

Background:

  • Schizophrenia is linked to dopamine system hyperactivity and reduced cerebral lateralization.
  • Behavioral lateralization, the preference for using one side of the body, is a measurable indicator of brain lateralization.

Purpose of the Study:

  • To investigate the relationship between dopamine system hyperactivity and behavioral lateralization.
  • To determine if increased dopamine levels impair the degree of behavioral lateralization.

Main Methods:

  • Utilized genetically engineered mice lacking the dopamine transporter (DAT) gene to model persistent hyperdopaminergia.
  • Assessed paw preference in DAT mutant mice and their littermates across different inbred genetic backgrounds (B6, D2, and B6xD2 F1).
  • Employed Collins' protocol for standardized paw preference testing.

Related Experiment Videos

Main Results:

  • Persistent hyperdopaminergia was found to significantly impair the degree of behavioral lateralization in mice.
  • The direction of paw preference was not affected by the hyperdopaminergic state.
  • This effect was consistent across different genetic backgrounds.

Conclusions:

  • The degree of behavioral lateralization is a valid phenotype for studying cerebral lateralization.
  • Findings support the dopamine hypothesis of schizophrenia and suggest a direct link between dopaminergic system hyperactivity and reduced lateralization.
  • Further genetic analysis of cerebral lateralization in both normal and pathological conditions can benefit from this phenotype.