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Updated: Aug 22, 2026

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
Published on: June 6, 2025
B cells: new ways to inhibit their function in rheumatoid arthritis
1Department of Medicine, University of Alabama at Birmingham, 409 LHRB, 701 19th Street South, Birmingham, AL 35294, USA. rcarter@uab.edu
Abstract:
The apparent efficacy of B-cell depletion in autoimmune diseases has increased interest in targeting B cells. One goal of next generation therapies is to develop treatments that block B-cell activation and preserve resting nonautoimmune cells that maintain B cell memory. To do so, one needs to understand how B cells are activated and what receptors and intracellular signaling pathways regulate this process. This paper will summarize B-cell activation pathways and illustrate how these are being targeted in the development of new treatments for rheumatoid arthritis.
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