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Comparative efficacy and safety of roxithromycin and clarithromycin in upper respiratory tract infections
E de Campora1, A Camaioni, M Leonardi
1Division of ORL, Fatebenefratelli Hospital, Rome, Italy.
Diagnostic Microbiology and Infectious Disease
|May 1, 1992
Abstract:
Roxithromycin 300 mg once daily was compared with clarithromycin 250 mg b.i.d. in an open randomized trial in 200 patients with upper respiratory tract infection: sinusitis, pharyngotonsillitis, and otitis media. Average treatment duration was 9 days. Roxithromycin was more effective (p less than 0.01) particularly in otitis media and pharyngotonsillitis, and better tolerated (only 4% side effects, p less than 0.05).