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Published on: February 7, 2013
[Unexpected occurence of hemoglobin Athens-Georgia]
R Granouillet1, S Atieh, A Francina
1Laboratoire de biochimie, CHU-hôpitaux de Saint Etienne, hôpital Nord.
Abstract:
The following report concerned a 47 year old Caucasian diabetic patient. Routine HPLC of HbA1c (Variant II Biorad Laboratories - hemoglobin A1c program) resulted only in the evidence of HbF (1%) and increase in HbA1c (10%). Considering the presence of HbF a standard agarose gel electrophoresis of patient's hemoglobin was performed and revealed the presence of Hb Athens-Georgia. Consequently the occurrence of HbF during determination of HbA1c by HPLC should lead to perform a standard hemoglobin electrophoresis in order to explore an hidden, unsuspected and clinically silent occurrence of rare Hb variant or additional unsuspected increase in HbA2.
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