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Selective inhibition of cough and bronchoconstriction in conscious guinea pigs
K Forsberg1, J A Karlsson, C Zackrisson
1Astra Draco AB, Lund, Sweden.
Respiration; International Review of Thoracic Diseases
|January 1, 1992
Abstract:
In guinea-pigs citric acid-induced cough and bronchoconstriction were inhibited by beta 2-agonist and xanthine drugs. Lidocaine inhibited only cough. Cromoglycate and ipratropium bromide inhibited only bronchoconstriction. We conclude that cough and bronchoconstriction in guinea-pigs are distinct reflexes and that the inhibitory pharmacology of these airway reflexes may agree in many respects, with that observed in asthmatic subjects.