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[Study on the modification surface material of heparinized polyurethane].

Shuxian Meng1, Xiaona Wen, Yaqing Feng

  • 1School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China.

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi = Journal of Biomedical Engineering = Shengwu Yixue Gongchengxue Zazhi
|September 11, 2004
PubMed
Summary

Researchers synthesized cationic and heparinized polyurethanes (PUs) with good biocompatibility. Laboratory tests confirmed their suitability for biological applications, demonstrating effective hemostatic and cellular interaction properties.

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Area of Science:

  • Polymer Chemistry
  • Biomaterials Science

Context:

  • Polyurethanes (PUs) are versatile biomaterials.
  • Developing PUs with enhanced biocompatibility is crucial for medical devices.

Purpose:

  • To synthesize and characterize cationic and heparinized polyurethanes (PUs).
  • To evaluate the biocompatibility of these novel PUs using various laboratory tests.

Summary:

  • Cationic and heparinized polyurethanes were synthesized via a two-step solution polymerization method.
  • Characterization included infrared spectroscopy, electron spectroscopy for chemical analysis (ESCA), and turbidity measurements.
  • Biocompatibility was confirmed through blood coagulation time (CT), activated partial thromboplastin time (APTT), and fibroblast culture assays.

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Impact:

  • The synthesized PUs exhibit excellent biocompatible properties.
  • These materials show potential for applications in biomedical devices requiring blood compatibility.