Related Experiment Video
Updated: Aug 10, 2026

09:15
Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
Published on: November 10, 2017
Facilitated lipid management using interactive e-mail: preliminary results of a randomized controlled trial
William T Lester1, Richard Grant, G Octo Barnett
1Laboratory of Computer Science, Massachusetts General Hospital, 50 Staniford Street, Boston, MA 02114, USA.
Studies in Health Technology and Informatics
|September 14, 2004
Summary
A new clinical decision support system, FastTrack, improved statin therapy initiation for hyperlipidemia patients. This informatics tool streamlines care, making cholesterol management more effective in clinical practice.
Area of Science:
- Clinical Informatics
- Cardiovascular Medicine
- Health Services Research
Background:
- Cholesterol control in hyperlipidemia management remains suboptimal despite evidence-based guidelines.
- Existing clinical practice faces barriers to effective hyperlipidemia management.
- There is a need for improved tools to support guideline adherence.
Purpose of the Study:
- To describe the design and implementation of the FastTrack clinical decision support system.
- To evaluate the impact of FastTrack on hyperlipidemia management in ambulatory care.
- To assess the efficiency of the FastTrack system for healthcare providers.
Main Methods:
- A randomized, controlled trial was conducted involving 14 physicians and 276 patients.
- The FastTrack system integrates clinical information, decision support, and action via email.
- Interim analysis focused on physician review time and initial treatment changes.
Main Results:
- Physicians reviewed and acted upon an average of 9 patient emails in under 15 minutes.
- Significantly more patients in the intervention group were initiated on statin therapy or had their dose increased (15.3% vs. 2.3%, p < 0.001).
- The system demonstrated efficiency in processing patient management tasks.
Conclusions:
- The FastTrack system is an effective informatics tool for improving hyperlipidemia management.
- The intervention shows promise in overcoming barriers to guideline-based cholesterol care.
- Further assessment of LDL level impact is pending trial completion.

