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A disease activity score for polymyalgia rheumatica.

B F Leeb1, H A Bird

  • 12nd Department of Medicine, Lower Austrian Centre for Rheumatology, Endocrinology, Humanisklinikum Lower Austria, A-2000 Stockerau, Landstrasse 18, Austria. leeb.khstockerau@aon.at

Annals of the Rheumatic Diseases
|September 14, 2004
PubMed
Summary

A new polymyalgia rheumatica activity score (PMR-AS) was developed to measure disease activity. This validated tool helps monitor patient response and disease progression effectively.

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Area of Science:

  • Rheumatology
  • Clinical Assessment Tools
  • Disease Activity Measurement

Background:

  • Polymyalgia rheumatica (PMR) requires reliable tools to monitor disease activity.
  • Existing assessment methods may lack comprehensive validation for PMR.

Purpose of the Study:

  • To develop a composite score for measuring polymyalgia rheumatica disease activity.
  • To assess the internal and external validity of this new PMR activity score (PMR-AS).

Main Methods:

  • A novel PMR activity score (PMR-AS) was designed using patient data from international and Austrian cohorts.
  • Internal consistency was evaluated using Cronbach's alpha; factor analysis determined item contribution.
  • PMR-AS values were compared over time using paired t tests and correlated with other clinical measures.

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Main Results:

  • The PMR-AS demonstrated high internal consistency (Cronbach's alpha 0.91 and 0.88).
  • All individual items significantly contributed to the total score, with equal weighting across cohorts.
  • The PMR-AS showed significant differences over time, correlating highly with global assessments, patient satisfaction, and ESR.

Conclusions:

  • The developed PMR-AS is an easily applicable and valid instrument for monitoring polymyalgia rheumatica disease activity.
  • Combined with PMR response criteria, the PMR-AS offers an improved method for describing treatment response.