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Thermosensation and pain.

Makoto Tominaga1, Michael J Caterina

  • 1Section of Cell Signaling, Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences, Okazaki 444-8787, Japan. tominaga@nips.ac.jp

Journal of Neurobiology
|September 14, 2004
PubMed
Summary

Mammals sense temperature through six TRP (transient receptor potential) channels. Some channels, like TRPV1, TRPV2, TRPM8, and TRPA1, are activated by noxious temperatures, indicating their role in thermal pain.

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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Sensory Physiology

Background:

  • Mammals perceive a broad spectrum of temperatures, with extreme heat and cold inducing pain.
  • Six thermosensitive ion channels, all belonging to the TRP superfamily, have been identified in mammals.

Purpose of the Study:

  • To investigate the role of TRP (transient receptor potential) channels in sensing noxious temperatures and mediating thermal pain.

Main Methods:

  • Review of existing literature on thermosensitive TRP channels.
  • Analysis of thermal activation thresholds for identified TRP channels.
  • Examination of evidence for TRPV1 involvement in thermal nociception using TRPV1-deficient mice models.

Main Results:

  • Six TRP channels (TRPV1-4, TRPM8, TRPA1) are involved in thermosensation.
  • TRPV1, TRPV2, TRPM8, and TRPA1 channels activate within noxious temperature ranges (>43°C, >52°C, <28°C, <17°C, respectively).
  • Evidence supports TRPV1's role in thermal nociception, with other channels likely involved due to their activation thresholds.

Conclusions:

  • TRP channels are crucial for detecting thermal stimuli, including painful temperatures.
  • TRPV1, TRPV2, TRPM8, and TRPA1 are key players in mammalian thermal pain perception.
  • Further research can elucidate the specific contributions of each TRP channel to thermal nociception.

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