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Triflupromazine: a microbicide non-antibiotic compound
Sujata G Dastidar1, Sanchayita Debnath, Kaushiki Mazumdar
1Division of Microbiology, Department of Pharmaceutical Technology, Jadavpur University, Calcutta, India. jumicrobiol@yahoo.co.in
Acta Microbiologica Et Immunologica Hungarica
|September 15, 2004
Summary
The phenothiazine triflupromazine shows strong antibacterial effects against various bacteria. This antipsychotic drug also protected mice against Salmonella typhimurium infection, reducing bacterial load.
Area of Science:
- Pharmacology
- Microbiology
- Infectious Diseases
Background:
- Phenothiazines are a class of drugs known for antipsychotic properties.
- Triflupromazine is a specific phenothiazine derivative with a unique chemical structure.
- The potential antibacterial activity of triflupromazine has not been extensively studied.
Purpose of the Study:
- To evaluate the antibacterial activity of triflupromazine against a wide range of bacterial strains.
- To determine the minimum inhibitory concentration (MIC) of triflupromazine.
- To assess the in vivo efficacy of triflupromazine against bacterial infection in a mouse model.
Main Methods:
- Agar dilution method was used to determine the MIC against 279 bacterial strains.
- In vivo study involved intraperitoneal injection of triflupromazine in Swiss albino mice.
- Bacterial challenge with Salmonella typhimurium and assessment of survival rates and bacterial load in organs and blood.
Main Results:
- Triflupromazine demonstrated significant antibacterial activity against both Gram-positive and Gram-negative bacteria.
- MIC values ranged from 2-50 microg/ml for Staphylococcus aureus and 5-100 microg/ml for shigellae and vibrios.
- Triflupromazine treatment significantly protected mice against Salmonella typhimurium infection and reduced bacterial counts in vivo.
Conclusions:
- Triflupromazine possesses notable broad-spectrum antibacterial properties.
- The drug offers significant protection in a murine model of Salmonella infection.
- Triflupromazine is a promising candidate for further investigation as an antibacterial agent.
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