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Related Experiment Video

Updated: Jul 20, 2026

Conformational Evaluation of HIV-1 Trimeric Envelope Glycoproteins Using a Cell-based ELISA Assay

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Published on: September 14, 2014

Defining criteria for broadly neutralizing HIV antibodies.

Elizabeth-Sharon David-Fung¹, Katherine A Belobrajdic¹, Jennifer P Macke¹

¹Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM, United States.

Frontiers in Immunology

|August 1, 2025

Summary

A small percentage of HIV-1 patients develop broadly neutralizing antibodies (bnAbs). A new tool, CAByN, helps define and identify these bnAbs from extensive neutralization data.

Keywords:

BNAB HIV antibody breadth broadly neutralizing antibodies potency

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Last Updated: Jul 20, 2026

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Published on: September 14, 2014

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Area of Science:

Immunology
Virology
Bioinformatics

Background:

A subset of individuals with HIV-1 infection develop broadly neutralizing antibodies (bnAbs).
These bnAbs are crucial for neutralizing diverse HIV-1 strains.
Currently, a universally accepted numerical definition for bnAbs is lacking.

Purpose of the Study:

To review key characteristics of HIV neutralizing antibodies and proposed bnAb definitions.
To introduce CAByN, a web-based tool for identifying bnAbs based on user-defined criteria.
To present biological insights derived from CAByN analysis.

Main Methods:

Review of existing literature on HIV neutralizing antibodies and bnAb definitions.
Development and utilization of the CAByN web tool.
Analysis of data from the Los Alamos HIV Databases CATNAP database.
Examination of antibody neutralization data across different viral clades.

Main Results:

CAByN allows users to apply numerical definitions to identify bnAbs.
Biological findings include differential neutralizing activity of certain antibodies against various HIV-1 clades.
The tool aids in identifying antibodies with potentially incomplete neutralization profiles.

Conclusions:

The CAByN tool provides a standardized approach to defining and identifying bnAbs.
It facilitates the exploration of antibody neutralization data, revealing nuanced biological activities.
This resource can advance research in HIV vaccine development and antibody-based therapies.