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Updated: Aug 22, 2026
07:25
A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
Abstract:
Although guidelines for androgen replacement therapy for older men have been developed by several groups, the data to support treatment are based on the results of only a small number of clinical trials. It has not been definitively established that the decline in testosterone seen in most aging men results in an androgen deficient state with health-related outcomes that can be improved by androgen therapy.
Insights
Guidelines for androgen replacement therapy in older men exist, but limited clinical trials show insufficient evidence that declining testosterone causes a deficiency treatable by therapy.
Area of Science:
- Endocrinology
- Geriatrics
- Men's Health
Background:
- Aging is associated with declining testosterone levels in men.
- Existing guidelines for androgen replacement therapy (ART) in older men have been proposed.
- The evidence base supporting ART in this population is limited.
Purpose of the Study:
- To evaluate the current evidence supporting androgen replacement therapy in aging men.
- To determine if testosterone decline in aging men constitutes a treatable androgen deficiency.
Main Methods:
- Review of existing clinical trial data on androgen replacement therapy.
- Analysis of the link between testosterone decline and health outcomes in older men.
Main Results:
- The data supporting ART are derived from a small number of clinical trials.
- It remains unproven that testosterone decline in aging men leads to a deficiency state.
- Health-related outcomes potentially improved by ART have not been definitively established.
Conclusions:
- Further robust clinical trials are needed to establish the efficacy and necessity of ART in aging men.
- The current evidence is insufficient to broadly recommend androgen replacement therapy for testosterone decline in older men.
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