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Characterization of the human immune response to the UK anthrax vaccine
Les Baillie1, Tim Townend, Nicki Walker
1Biodefense Vaccines, Biological Defense Research Directorate, Naval Medical Research Center, Silver Spring, MD 20910-7500, USA. bailliel@mmrc.navy.mil
Abstract:
The anthrax bipartite lethal toxin (protective antigen (PA) and lethal factor (LF))-specific antibody responses of humans receiving the UK licensed anthrax vaccine were determined. The PA-specific IgG response peaked two weeks post immunization and fell back to pre-boost levels by week 12. The heterogeneity of the host population modulated the extent of the PA-specific antibody response. Significantly lower levels of LF-specific antibodies were also detected. Vaccinated individuals recognized the same PA epitope as the protective mouse lethal toxin neutralizing monoclonal 2D3 suggesting that this may also be a target for human protection.
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