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Neurologic impairment 10 years after optic neuritis
Roy W Beck1, Craig H Smith, Robin L Gal
1Jaeb Center for Health Research, 15310 Amberly Drive, Tampa, FL 33647, USA.
Archives of Neurology
|September 15, 2004
Summary
Most patients developing multiple sclerosis after optic neuritis experience mild disability for at least 10 years. Baseline MRI scans showing lesions did not predict long-term neurologic disability in these cases.
Area of Science:
- Neuroscience
- Clinical Neurology
- Ophthalmology
Background:
- Optic neuritis is a significant risk factor for developing multiple sclerosis (MS).
- Long-term observational studies are crucial for understanding the prognosis of MS following optic neuritis.
Purpose of the Study:
- To evaluate the long-term neurologic disability in patients 10 to 12 years post-optic neuritis.
- To determine the relationship between baseline MRI findings and subsequent disability in MS patients.
Main Methods:
- A longitudinal follow-up of 127 patients from the Optic Neuritis Treatment Trial who developed clinically definite MS.
- Standardized neurologic examinations and assessments using the Functional Systems Scale and Expanded Disability Status Scale (EDSS).
Main Results:
- The majority of patients (65%) had a mild disability (EDSS < 3.0) at 10-12 years.
- No significant correlation was found between baseline MRI lesion status or number of lesions and the degree of disability.
- Two deaths occurred due to severe MS, one in a patient with no baseline MRI lesions.
Conclusions:
- Patients developing MS after optic neuritis generally experience a mild, benign clinical course for at least a decade.
- Baseline MRI findings may not accurately predict long-term disability in this patient cohort.