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Isolation of Perivascular Multipotent Precursor Cell Populations from Human Cardiac Tissue
Published on: October 8, 2016
Circulating endothelial cell count as a diagnostic marker for non-ST-elevation acute coronary syndromes
Jacques Quilici1, Nathalie Banzet, Philippe Paule
1Département de Cardiologie, Hôpital Timone Adultes, Marseille, France.
Circulation
|September 15, 2004
Summary
Circulating endothelial cell (CEC) counts serve as an early, specific marker for non-ST-elevation acute coronary syndromes (ACS). Combining CEC counts with troponin I improves early ACS diagnosis, especially when troponin levels are initially normal.
Area of Science:
- Cardiovascular Medicine
- Biomarker Discovery
- Diagnostic Imaging
Background:
- Endothelial cell shedding occurs in various vascular disorders.
- Circulating endothelial cells (CECs) are released from damaged endothelium.
- Non-ST-elevation acute coronary syndromes (ACS) require timely diagnosis.
Purpose of the Study:
- To assess the diagnostic utility of circulating endothelial cell (CEC) count for non-ST-elevation ACS.
- To evaluate CEC count as an early diagnostic marker compared to troponin I.
- To explore the combined diagnostic potential of CEC count and troponin I.
Main Methods:
- CEC counts were measured in 200 patients (60 with non-ST-elevation ACS, 40 controls) at 0, 4, and 8 hours post-admission.
- CEC counts were compared with troponin I levels.
- Receiver operating characteristic (ROC) curves were analyzed.
Main Results:
- Elevated CEC counts (>3 cells/mL) were observed in 32 ACS patients, indicating early detection.
- CEC elevation occurred significantly sooner than troponin I elevation.
- A subgroup of ACS patients with normal troponin I showed high CEC counts, improving early diagnosis by 30%.
Conclusions:
- CEC count is an early, specific, and independent diagnostic marker for non-ST-elevation ACS.
- A combined strategy of CEC count and troponin I offers an effective diagnostic approach.
- CEC measurement aids in early ACS diagnosis, particularly in troponin-negative cases.
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