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Updated: Aug 22, 2026

Intralymphatic Immunotherapy and Vaccination in Mice
Published on: February 2, 2014
Allergy symptom response to intradermal testing-based immunotherapy: a retrospective study of clinical practice
David Rouse1, Debra L Park, Thomas Sanford
1Department of Otolaryngology Head and Neck Surgery, University of Kansas Medical Center, Kansas City, Kansas, USA. drouse@kumc.edu
Objective:
Evaluate the multiple end-organ targets affected by intradermal testing (IDT)-based immunotherapy. Study design and setting We conducted a retrospective medical record review of 139 patients, as well as a follow-up questionnaire in a university setting.
Results:
Statistically significant differences (t-tests, P < 0.05) were observed in the prevalence of symptoms after IDT-based immunotherapy for each category (ear, eye, nasal, and throat). When divided into treatment time groups, the reduction was less in the first group (0-6 months therapy), than the subsequent groups (6-24 months and >24 months). The reduction leveled off after 6 months of therapy, with no difference seen between the 6- to 24-month and >24-month groups.
Conclusions:
IDT-based immunotherapy has a broad response on otolaryngic allergy symptoms that appears to be consistent over time.
Significance:
IDT-based immunotherapy is an effective form of treatment for allergy-induced diseases of the head and neck.
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